Jean Smart
Dr. Ann Possible (voice)
John DiMaggio
Dr. Drakken (voice)
Nicole Sullivan
Shego (voice)
Estelle Harris
Mrs. Lipsky (voice)
Roz Ryan
Mrs. Load (voice)
Shaun Fleming
Tim Possible / Jim Possible (voice)
Andrea Martin
Mrs. Stoppable (voice)
Gary Cole
Dr. James Possible (voice)
Frank Welker
Scientist (voice)
