Jean Smart
Dr. Ann Possible (voice)
John DiMaggio
Dr. Drakken (voice)
Nicole Sullivan
Shego (voice)
Maurice LaMarche
Scientist #1 (voice)
Rob Paulsen
Scientist #2 / Hank Perkins (voice)
Brian George
Duff Killigan (voice)
Patrick Warburton
Steve Barkin (voice)
Shaun Fleming
Tim Possible / Jim Possible (voice)
