Jean Smart
Dr. Ann Possible (voice)
John DiMaggio
Dr. Drakken (voice)
Nicole Sullivan
Shego (voice)
Enrico Colantoni
Dr. Cyrus Bortel (voice)
Dan Castellaneta
Mr. Geminini (voice)
Shaun Fleming
Tim Possible / Jim Possible (voice)
Gary Cole
Dr. James Possible (voice)
